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human INTS6 Adenovirus

Name 
Ad-h-INTS6
Cat No 
ADV-212325
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human INTS6.

ADV-212325
Ad-h-INTS6

Ready-to-use Adenovirus expressing Human INTS6 (integrator complex subunit 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DBI-1; DDX26; DDX26A; DEAD box protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26; DICE1; HDB; INT6; integrator complex subunit 6; Notchl2; Protein DDX26; protein deleted in cancer 1; RNA helicase HDB
Description (eCommerce)
DDX26/DICE1 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX26/DICE1 is a subunit of the integrator complex involved in 3’-end processing of snRNAs. DDX26/DICE1 is implicated as a tumor suppressor, and its ectopic expression has been shown to inhibit tumor cell growth. Alternative names for DDX26/DICE1 include integrator complex subunit 6, Int6, protein deleted in cancer 1, protein DDX26, DBI-1, deleted in cancer 1, INTS6, DDX26A, HDB, Nochl2, and DKFZP434B105.
Description (Vector)
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.
Gene ID
26512
Gene Name (eCommerce)
integrator complex subunit 6
Gene Name (Vector)
integrator complex subunit 6
Gene Symbol
INTS6
HGNC ID
HGNC:14879
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2664
ORF Size (bp)
2664 bp
Protein Name (eCommerce)
Integrator complex subunit 6
RefSeq ID
NM_012141
RefSeq Synonyms
NM_012141, NM_001306091, NM_001039938, NM_001039937, BC039829,
Research Areas
Cancer,Cytoskeleton,Helicase Activity,RNA Processing,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
DDX26/DICE1 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX26/DICE1 is a subunit of the integrator complex involved in 3’-end processing of snRNAs. DDX26/DICE1 is implicated as a tumor suppressor, and its ectopic expression has been shown to inhibit tumor cell growth. Alternative names for DDX26/DICE1 include integrator complex subunit 6, Int6, protein deleted in cancer 1, protein DDX26, DBI-1, deleted in cancer 1, INTS6, DDX26A, HDB, Nochl2, and DKFZP434B105.
UniGene ID
Hs.439440
UniProt ID (eCommerce)
Q9UL03

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.