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human IARS Adenovirus

Name 
Ad-h-IARS
Cat No 
ADV-211738
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human IARS.

ADV-211738
Ad-h-IARS

Ready-to-use Adenovirus expressing Human IARS (isoleucyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GRIDHH; IARS1; ILERS; ILRS; IRS; isoleucine tRNA ligase 1, cytoplasmic; isoleucine--tRNA ligase, cytoplasmic; Isoleucyl-tRNA synthetase; PRO0785
Description (eCommerce)
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase (IARS) belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis [taken from NCBI Entrez Gene (Gene ID: 3376)].
Description (Vector)
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs.
Gene ID
3376
Gene Name (eCommerce)
isoleucyl-tRNA synthetase
Gene Name (Vector)
isoleucyl-tRNA synthetase
Gene Symbol
IARS
HGNC ID
HGNC:5330
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3168
ORF Size (bp)
3168 bp
Protein Name (eCommerce)
Isoleucine--tRNA ligase, cytoplasmic
RefSeq ID
NM_002161
RefSeq Synonyms
NM_013417, NM_002161, BC065552,
Research Areas
Gene Expression,Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase (IARS) belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis [taken from NCBI Entrez Gene (Gene ID: 3376)].
UniGene ID
Hs.445403
UniProt ID (eCommerce)
P41252

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.