human IKKa shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human IKKa gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this human gene was validated by western blot in A549 cells.
1841
Ad-h-IKKa-shRNA
Ready-to-use human IKKa shRNA Adenovirus. human IKKa shRNA adenovirus gene knockdown1841
Gene Reference Data
Alternate Names
Conserved helix-loop-helix ubiquitous kinase; IkappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; IkB kinase alpha subunit; IKBKA; IKK1; IKKA; IKK-A; IKK-a kinase; IKK-alpha; inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; TCF16; TCF-16; transcription factor 16
Description (eCommerce)
I kappa-B kinase-alpha (IKK-alpha) is part of the IKK complex composed of two regulatory subunits, IKK-alpha and IKK-beta, and a regulatory subunit, IKK-gamma/NEMO. The IKK complex functions to phosphorylate and inactivate I kappa B, an inhibitor of the NF-kappa B transcription factor.
Description (Vector)
CHUK encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Gene ID
1147
Gene Name (eCommerce)
conserved helix-loop-helix ubiquitous kinase
Gene Name (Vector)
conserved helix-loop-helix ubiquitous kinase
Gene Symbol
CHUK
HGNC ID
HGNC:1974
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2238
ORF Size (bp)
2238 bp
Protein Name (eCommerce)
Inhibitor of nuclear factor kappa-B kinase subunit alpha
RefSeq ID
NM_001278
RefSeq Synonyms
NM_001320928, NM_001278, BC092514,
Research Areas
Apoptosis,B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cell Cycle,Cytokine Signaling,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,FoxO Signaling,Gene Expression,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,RANKL-RANK Signaling,Response to Virus,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,TRAIL Signaling,TWEAK Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
I kappa-B kinase-alpha (IKK-alpha) is part of the IKK complex composed of two regulatory subunits, IKK-alpha and IKK-beta, and a regulatory subunit, IKK-gamma/NEMO. The IKK complex functions to phosphorylate and inactivate I kappa B, an inhibitor of the NF-kappa B transcription factor.
UniGene ID
Hs.198998
UniProt ID (eCommerce)
O15111
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.