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human GARS Adenovirus

Name 
Ad-h-GARS
Cat No 
ADV-209650
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human GARS.

ADV-209650
Ad-h-GARS

Ready-to-use Adenovirus expressing Human GARS (glycyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AP-4-A synthetase; Charcot-Marie-Tooth neuropathy 2D; Charcot-Marie-Tooth neuropathy, neuronal type, D; CMT2D; diadenosine tetraphosphate synthetase; DSMAV; glycine--tRNA ligase; Glycyl-tRNA synthetase; GlyRS; HMN5; SMAD1
Description (eCommerce)
Glycyl-tRNA synthetase (GARS) catalyzes the attachment of glycine to tRNA(Gly). It is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P41250].
Description (Vector)
GARS encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
Gene ID
2617
Gene Name (eCommerce)
glycyl-tRNA synthetase
Gene Name (Vector)
glycyl-tRNA synthetase
Gene Symbol
GARS
HGNC ID
HGNC:4162
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2220
ORF Size (bp)
2220 bp
Protein Name (eCommerce)
Glycine--tRNA ligase
RefSeq ID
NM_002047
RefSeq Synonyms
NM_002047, NM_001316772, BC007755, BC007722, BC000065,
Research Areas
Apoptosis,Gene Expression,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,Translational Control
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Glycyl-tRNA synthetase (GARS) catalyzes the attachment of glycine to tRNA(Gly). It is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P41250].
UniGene ID
Hs.404321
UniProt ID (eCommerce)
P41250

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.