Deoxyribonuclease I Adenovirus
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.
1612
Ad-DNASE I
Ready-to-use Deoxyribonuclease I Adenovirus. Ad-DNASE I, Deoxyribonuclease I, Dnase I, DNL1, DNASE1, DNASE-1 adenovirus 1612
Gene Reference Data
Alternate Names
DNL1; DRNI
Description (Vector)
DNASE1 encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Gene ID
1773
Gene Name (Vector)
deoxyribonuclease 1
Gene Symbol
DNASE1
HGNC ID
HGNC:2956
ORF Size (aa)
849
ORF Size (bp)
849 bp
RefSeq ID
NM_005223
RefSeq Synonyms
NM_005223, BC029437,
Species
human
UniGene ID
Hs.629638
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.