human FNTA Adenovirus

Name 
Ad-h-FNTA
Cat No 
ADV-209212
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human FNTA.

ADV-209212
Ad-h-FNTA

Ready-to-use Adenovirus expressing Human FNTA (farnesyltransferase, CAAX box, alpha). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CAAX farnesyltransferase subunit alpha; farnesyl-protein transferase alpha-subunit; FPTA; FTase-alpha; GGTase-I-alpha; PGGT1A; protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; protein prenyltransferase alpha subunit repeat containing 2; PTAR2; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha
Description (eCommerce)
Farnesyl-protein transferase alpha-subunit (FNTA) catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49354].
Description (Vector)
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13.
Gene ID
2339
Gene Name (eCommerce)
farnesyltransferase, CAAX box, alpha
Gene Name (Vector)
farnesyltransferase, CAAX box, alpha
Gene Symbol
FNTA
HGNC ID
HGNC:3782
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1140
ORF Size (bp)
1140 bp
Protein Name (eCommerce)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
RefSeq ID
NM_002027
RefSeq Synonyms
NM_002027, BC084566,
Research Areas
Apoptosis,Neurobiology,Signal Transduction,TGF-beta Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology,signal_transduction,immunology
Species
human
Target Sentence
Farnesyl-protein transferase alpha-subunit (FNTA) catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49354].
UniGene ID
Hs.370312
UniProt ID (eCommerce)
P49354

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.