human FNBP1 Adenovirus

Name 
Ad-h-FNBP1
Cat No 
ADV-209196
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human FNBP1.

ADV-209196
Ad-h-FNBP1

Ready-to-use Adenovirus expressing Human FNBP1 (formin binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
FBP17; formin-binding protein 1; formin-binding protein 17; hFBP17
Description (eCommerce)
FBP17 may act as a link between RND2 signaling and regulation of the actin cytoskeleton. FBP17 is required for the coordination of membrane tubulation and reorganization of the actin cytoskeleton during endocytosis. FBP17 binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. It also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. FBP17 may be required for the lysosomal retention of FASLG/FASL [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96RU3].
Description (Vector)
FNBP1 is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.
Gene ID
23048
Gene Name (eCommerce)
formin binding protein 1
Gene Name (Vector)
formin binding protein 1
Gene Symbol
FNBP1
HGNC ID
HGNC:17069
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1824
ORF Size (bp)
1824 bp
Protein Name (eCommerce)
Formin-binding protein 1
RefSeq ID
NM_015033
RefSeq Synonyms
NM_015033, BC143515, BC143514, BC143513, BC101755,
Research Areas
Cytoskeleton,Lysosome,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,neurobiology,developmental_biology
Species
human
Target Sentence
FBP17 may act as a link between RND2 signaling and regulation of the actin cytoskeleton. FBP17 is required for the coordination of membrane tubulation and reorganization of the actin cytoskeleton during endocytosis. FBP17 binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. It also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. FBP17 may be required for the lysosomal retention of FASLG/FASL [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96RU3].
UniGene ID
Hs.189409
UniProt ID (eCommerce)
Q96RU3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.