human FLCN Adenovirus
This is an Adenovirus expressing Human CDK5R2.
ADV-209082
Ad-h-FLCN
Ready-to-use Adenovirus expressing Human FLCN (folliculin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BHD; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein; FLCL; folliculin
Description (eCommerce)
Defects in the folliculin (FLCN) gene are the cause of Birt-Hogg-Dube syndrome (BHD) [MIM:135150]. BHD is a rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax. Fibrofolliculomas are part of the triad of BHD skin lesions that also includes trichodiscomas and acrochordons. Defects in FLCN may also be the cause of primary spontaneous pneumothorax (PSP) [MIM:173600], a condition in which air is present in the pleural space in the absence of a precipitating event, such as trauma or lung disease. Folliculin may be a tumor suppressor involved in colorectal and renal cell tumorigenesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8NFG4].
Description (Vector)
FLCN is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Gene ID
201163
Gene Name (eCommerce)
folliculin
Gene Name (Vector)
folliculin
Gene Symbol
FLCN
HGNC ID
HGNC:27310
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1029
ORF Size (bp)
1029 bp
Protein Name (eCommerce)
Folliculin
RefSeq ID
NM_144997
RefSeq Synonyms
NM_144997, NM_144606, BC015687,
Research Areas
Cancer,Kidney Cancer,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer
Species
human
Target Sentence
Defects in the folliculin (FLCN) gene are the cause of Birt-Hogg-Dube syndrome (BHD) [MIM:135150]. BHD is a rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax. Fibrofolliculomas are part of the triad of BHD skin lesions that also includes trichodiscomas and acrochordons. Defects in FLCN may also be the cause of primary spontaneous pneumothorax (PSP) [MIM:173600], a condition in which air is present in the pleural space in the absence of a precipitating event, such as trauma or lung disease. Folliculin may be a tumor suppressor involved in colorectal and renal cell tumorigenesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8NFG4].
UniGene ID
Hs.513975
UniProt ID (eCommerce)
Q8NFG4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.