Diablo homolog (Drosophila) Adenovirus
Smac (for second mitochondria-derived activator of caspase, also designated DIABLO in mouse for direct IAP [inhibitor of apoptosis protein] binding protein with low PI) promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding IAPs and removing their inhibitory activity. In healthy cells, Smac resides in the mitochondria, but when cells undergo apoptosis, Smac is released into the cytosol.
1587
Ad-DIABLO
Ready-to-use Diablo homolog (Drosophila) Adenovirus. Ad-DIABLO, Diablo homolog (Drosophila), SMAC, SMAC3, DIABLO, DIABLO-S adenovirus 1587
Gene Reference Data
Alternate Names
DFNA64; SMAC
Description (Vector)
DIABLO encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
Gene ID
56616
Gene Name (Vector)
diablo IAP-binding mitochondrial protein
Gene Symbol
DIABLO
HGNC ID
HGNC:21528
ORF Size (aa)
720
ORF Size (bp)
720 bp
RefSeq ID
NM_019887
RefSeq Synonyms
NM_138930, NM_138929, NM_019887, NM_001278342, NM_001278304, NM_001278303, NM_001278302, BC095468, BC011909,
Species
human
UniGene ID
Hs.169611
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.