Vav 1 oncogene Adenovirus

Name 
Ad-VAV1
Cat No 
1581
Availability
Immediate
Categories
Adenovirus, Over-Expression

Guanine nucleotide exchange factors (GEFs) regulate the activity of the small GTP-binding proteins of the Ras superfamily. The Ras family of proteins participate in a diverse array of functions, including signal transduction, cytoskeleton dynamics and intracellular trafficking. Ras proteins cycle between a biologically inactive GDP-bound state and an active GTP-bound state. GEFs catalyze the release of GDP from inactive Ras proteins to enable GTP binding. They include Vav, Vav2, Sos1, Sos2, RCC1, RhoGEF p115, Tiam1, Tiam2, Ral GDS, Ras-GRF1, Ras-GRF2, RasGRP, C3G, FGD1, FGD2, FGD3, NET1, Lbc, Lfc, Lsc, Ost, Frabin, Brx, Dble, Gem and Ect2. Vav has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

1581
Ad-VAV1

Ready-to-use Vav 1 oncogene Adenovirus. Ad-VAV1, Vav 1 oncogene, VAV, VAV1 adenovirus 1581

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene
Description (eCommerce)
VAV1 couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15498].
Description (Vector)
VAV1 is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
7409
Gene Name (eCommerce)
vav guanine nucleotide exchange factor 1
Gene Name (Vector)
vav 1 guanine nucleotide exchange factor
Gene Symbol
VAV1
HGNC ID
HGNC:12657
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2373
ORF Size (bp)
2373 bp
Protein Name (eCommerce)
Proto-oncogene vav
RefSeq ID
NM_005428
RefSeq Synonyms
NM_005428, NM_001258207, NM_001258206, BC013361,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cancer,Cytokine Signaling,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,GPCR Signaling,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prolactin Signaling,RAC1 Signaling,Rho Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,immunology,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
VAV1 couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15498].
UniGene ID
Hs.116237
UniProt ID (eCommerce)
P15498

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.