Suppressor of cytokine signaling 2 Adenovirus

Name 
Ad-SOCS2
Cat No 
1579
Availability
Immediate
Categories
Adenovirus, Over-Expression

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.

1579
Ad-SOCS2

Ready-to-use Suppressor of cytokine signaling 2 Adenovirus. Ad-SOCS2, Suppressor of cytokine signaling 2, CIS2, SSI2, CISH2, SOCS2, SSI-2, SOCS-2, STATI2 adenovirus 1579

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
Description (Vector)
SOCS2 encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. SOCS2 has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
Gene ID
8835
Gene Name (Vector)
suppressor of cytokine signaling 2
Gene Symbol
SOCS2
HGNC ID
HGNC:19382
ORF Size (aa)
597
RefSeq ID
NM_003877
RefSeq Synonyms
NM_003877, NM_001270471, NM_001270470, NM_001270469, NM_001270468, NM_001270467, BC010399,
Species
human
UniGene ID
Hs.485572

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.