Serum amyloid A1 Adenovirus
Inflammation results in a rapid increase in blood levels of acute phase proteins synthesized by hepatocytes in response to cytokines. Pentraxins, which include C reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins. CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding. Human serum amyloid A (SAA) is also a major acute-phase protein and precursor to amyloid A protein (AA), which is the major constituent of the fibril deposits of reactive amyloidosis.
1569
Ad-SAA1
Ready-to-use Serum amyloid A1 Adenovirus. Ad-SAA1, Serum amyloid A1, SAA, PIG4, SAA1, TP53I4 adenovirus 1569
Gene Reference Data
Alternate Names
PIG4; SAA; SAA2; TP53I4
Description (Vector)
SAA1 encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
Gene ID
6288
Gene Name (Vector)
serum amyloid A1
Gene Symbol
SAA1
HGNC ID
HGNC:10513
ORF Size (aa)
369
RefSeq ID
NM_000331
RefSeq Synonyms
NM_199161, NM_001178006, NM_000331, BC105796, BC007022,
Species
human
UniGene ID
Hs.632144
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.