human FAM126A Adenovirus

Name 
Ad-h-FAM126A
Cat No 
ADV-208373
Availability
4-5 weeks

This is an Adenovirus expressing Human CCL21.

ADV-208373
Ad-h-FAM126A

Ready-to-use Adenovirus expressing Human FAM126A (family with sequence similarity 126 member A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
down regulated by Ctnnb1, a; down-regulated by CTNNB1 protein A; DRCTNNB1A; HCC; HLD5; HYCC1; hyccin; Protein FAM126A
Description (eCommerce)
FAM126A is a component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). FAM126A may also have a role in the beta-catenin/Lef signaling pathway (Probable) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BYI3].
Description (Vector)
FAM126A may play a part in the beta-catenin/Lef signaling pathway. Expression of this gene is down-regulated by beta-catenin. Defects in this gene are a cause of hypomyelination with congenital cataract (HCC).
Gene ID
84668
Gene Name (eCommerce)
family with sequence similarity 126 member A
Gene Name (Vector)
family with sequence similarity 126 member A
Gene Symbol
FAM126A
HGNC ID
HGNC:24587
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1566
ORF Size (bp)
1566 bp
Protein Name (eCommerce)
Hyccin
RefSeq ID
NM_032581
RefSeq Synonyms
NM_032581, BC018710,
Research Areas
Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology
Species
human
Target Sentence
FAM126A is a component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). FAM126A may also have a role in the beta-catenin/Lef signaling pathway (Probable) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BYI3].
UniGene ID
Hs.85603
UniProt ID (eCommerce)
Q9BYI3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.