Protein kinase C, zeta Adenovirus

Name 
Ad-PKC-Zeta
Cat No 
1541
Availability
Immediate
Categories
Adenovirus, Over-Expression

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth, differentiation, gene expression, and hormone action. PKCs are protein serine/threonine kinases whose activities are dependent on calcium and phospholipids. PKCs can be subdivided into two major classes, including conventional (c) PKC isoforms and novel (n) isoforms. A more recently described member of this family has been designated either PKC µ for the human protein or PKD for isolates of mouse origin. Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC

1541
Ad-PKC-Zeta

Ready-to-use Protein kinase C, zeta Adenovirus. Ad-PKC-Zeta, “Protein kinase C, zeta”, PKC2, PRKCZ, PKC-zeta adenovirus 1541

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
PKC-ZETA; PKC2
Description (Vector)
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
5590
Gene Name (Vector)
protein kinase C zeta
Gene Symbol
PRKCZ
HGNC ID
HGNC:9412
ORF Size (aa)
1779
ORF Size (bp)
1779 bp
RefSeq ID
NM_002744
RefSeq Synonyms
NM_002744, NM_001242874, NM_001033582, NM_001033581, BC014270, BC008058,
Species
human
UniGene ID
Hs.496255

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.