POU domain, class 2, transcription factor 1 Adenovirus

Name 
Ad-OCT-I
Cat No 
1500
Availability
Immediate
Categories
Adenovirus, Over-Expression

POU (Pit, Oct, Unc) homeodomain proteins are transcriptional regulators that function in various developmental processes such as cell division, differentiation, specification and survival of specific cell types and participation in the determination of cell fate. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions tethered by a variable linker of 14¬ø26 amino acids. The versatility of POU protein operation is additionally conferred at the dimerization level. Transcription factors containing the POU homeodomain are important regulators of tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. There are five classes of POU Domain Family proteins. Pit-1 is a member of class I; Bob 1, Skn-1a/i, Oct-1 and Oct-2 are members of class II; Oct-6, Brn-1 and Brn-2 are members of class III; Brn-3 is a member of class IV; and Oct-3 (Oct-4) is a member of class V.

1500
Ad-OCT-I

Ready-to-use POU domain, class 2, transcription factor 1 Adenovirus. Ad-OCT-I, “POU domain, class 2, transcription factor 1”, OCT1, OTF1, POU2F1 adenovirus 1500

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
NF-A1; OCT1; oct-1; oct-1B; octamer-binding protein 1; octamer-binding transcription factor 1; Octamer-binding transcription factor-1; OTF1; OTF-1; POU class 2 homeobox 1 isoform Oct-1R; POU domain, class 2, transcription factor 1
Description (eCommerce)
OCT1 is a transcription factor that binds the octamer motif 5’-ATTTGCAT-3’ in promoters of various genes. OCT1 contains one homeobox DNA binding domain and is part of the POU transcription factor family due to the presence of one POU domain, a highly charged motif that selectively binds the octamer motif.
Description (Vector)
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 (PubMed 8314572)). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.(supplied by OMIM, Jul 2010)
Gene ID
5451
Gene Name (eCommerce)
POU class 2 homeobox 1
Gene Name (Vector)
POU class 2 homeobox 1
Gene Symbol
POU2F1
HGNC ID
HGNC:9212
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2232
ORF Size (bp)
2232 bp
Protein Name (eCommerce)
POU domain, class 2, transcription factor 1
RefSeq ID
NM_002697
RefSeq Synonyms
NM_002697, NM_001198786, NM_001198783, BC052274, BC003571, BC001664,
Research Areas
Gene Expression,Immunology,Neurobiology,T-cell Receptor Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
OCT1 is a transcription factor that binds the octamer motif 5’-ATTTGCAT-3’ in promoters of various genes. OCT1 contains one homeobox DNA binding domain and is part of the POU transcription factor family due to the presence of one POU domain, a highly charged motif that selectively binds the octamer motif.
UniGene ID
Hs.493649
UniProt ID (eCommerce)
P14859

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.