human DR1 Adenovirus
This is an Adenovirus expressing Human DR1.
ADV-207318
Ad-h-DR1
Ready-to-use Adenovirus expressing Human DR1 (down-regulator of transcription 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Down-regulator of transcription 1; NC2; NC2B; NC2-BETA; NCB2; negative cofactor 2; negative cofactor 2-beta; protein Dr1; TATA-binding protein-associated phosphoprotein
Description (eCommerce)
DR1 (Down-Regulator of Transcription 1) is one of two subunits (DR1 and Drap1) that make up the NC2 (Negative Co-factor 2) complex. Via it association with TATA-binding protein, NC2 functions as a regulator of transcription. In the NC2 complex DR1 is proposed to be responsible for the repressive activities of NC2.
Description (Vector)
DR1 encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Gene ID
1810
Gene Name (eCommerce)
down-regulator of transcription 1
Gene Name (Vector)
down-regulator of transcription 1
Gene Symbol
DR1
HGNC ID
HGNC:3017
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
531
ORF Size (bp)
531 bp
Protein Name (eCommerce)
Protein Dr1
RefSeq ID
NM_001938
RefSeq Synonyms
NM_001938, BC068553, BC035507, BC002809,
Research Areas
Histone Modification,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
DR1 (Down-Regulator of Transcription 1) is one of two subunits (DR1 and Drap1) that make up the NC2 (Negative Co-factor 2) complex. Via it association with TATA-binding protein, NC2 functions as a regulator of transcription. In the NC2 complex DR1 is proposed to be responsible for the repressive activities of NC2.
UniGene ID
Hs.348418
UniProt ID (eCommerce)
Q01658
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.