Phosphatidylserine receptor Adenovirus
Cells undergoing apoptosis lose the asymmetry of plasma membrane phospholipids and phosphatidylserine is exposed on the outer surface of the membrane. The phosphatidylserine receptor (PSR) specifically recognizes phosphatidylserine and this binding triggers the phagocytosis of apoptotic cells by either macrophages or dendritic cells. PSR is expressed on the surface of macrophages, fibroblasts, and epithelial cells, and it has been detected in high levels in heart, skeletal muscle, and kidney tissues at a molecular weight of 70 kDa due to glycosylation.
1471
Ad-PSR
Ready-to-use Phosphatidylserine receptor Adenovirus. Ad-PSR, Phosphatidylserine receptor, PSR,PTDSR,PTDSR1,KIAA0585 adenovirus 1471
Gene Reference Data
Alternate Names
arginine demethylase and lysine hydroxylase; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; histone arginine demethylase JMJD6; jmjC domain-containing protein 6; jumonji domain containing 6; jumonji domain-containing protein 6; lysyl-hydroxylase JMJD6; peptide-lysine 5-dioxygenase JMJD6; phosphatidylserine receptor; Protein PTDSR; PSR; PTDSR; PTDSR1
Description (eCommerce)
JMJD6 is a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. JMJD6 was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, [taken from NCBI Entrez Gene (Gene ID: 23210)].
Description (Vector)
JMJD6 encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
23210
Gene Name (eCommerce)
jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Gene Name (Vector)
arginine demethylase and lysine hydroxylase
Gene Symbol
JMJD6
HGNC ID
HGNC:19355
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1212
ORF Size (bp)
1212 bp
Protein Name (eCommerce)
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
RefSeq ID
NM_015167
RefSeq Synonyms
NM_015167, NM_001081461, BC066654,
Research Areas
Angiogenesis,Apoptosis,Cardiac Development,Cardiology,Cardiovascular,Gene Expression,Histone Modification,Immunology,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Transcription Factor / Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
JMJD6 is a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. JMJD6 was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, [taken from NCBI Entrez Gene (Gene ID: 23210)].
UniGene ID
Hs.514505
UniProt ID (eCommerce)
Q6NYC1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.