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human DOCK4 Adenovirus

Name 
Ad-h-DOCK4
Cat No 
ADV-207230
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human DOCK4.

ADV-207230
Ad-h-DOCK4

Ready-to-use Adenovirus expressing Human DOCK4 (dedicator of cytokinesis 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
dedicator of cytokinesis protein 4
Description (eCommerce)
DOCK4 (dedicator of cytokinesis 4) is a member of the CDM gene family and functions as a guanine nucleotide exchange factor (GEF) for the Rac small GTPase. It has been found to play a role in regulating the development of dendrites and rac-dependent cell migration. As a regulator of Rac, DOCK4 participates in wnt signaling by acting as a scaffold and influencing beta-catenin stability.
Description (Vector)
DOCK4 is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.
Gene ID
9732
Gene Name (eCommerce)
dedicator of cytokinesis 4
Gene Name (Vector)
dedicator of cytokinesis 4
Gene Symbol
DOCK4
HGNC ID
HGNC:19192
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5901
ORF Size (bp)
5901 bp
Protein Name (eCommerce)
Dedicator of cytokinesis protein 4
RefSeq ID
NM_014705
RefSeq Synonyms
NM_014705, BC117694, BC117689, BC117688,
Research Areas
Cancer,EGFR Signaling,Neurobiology,PDGF Signaling,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction,neurobiology
Species
human
Target Sentence
DOCK4 (dedicator of cytokinesis 4) is a member of the CDM gene family and functions as a guanine nucleotide exchange factor (GEF) for the Rac small GTPase. It has been found to play a role in regulating the development of dendrites and rac-dependent cell migration. As a regulator of Rac, DOCK4 participates in wnt signaling by acting as a scaffold and influencing beta-catenin stability.
UniGene ID
Hs.654652
UniProt ID (eCommerce)
Q8N1I0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.