Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 / TAK1 binding protein Adenovirus

Name 
Ad-TAB1
Cat No 
1456
Availability
Immediate
Categories
Adenovirus, Over-Expression

TAB1 and TAB2 (for TAK1 binding proteins) interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGF-beta mediatied signaling. In response to IL-1, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. TAB1 also plays a central role in a p38-alpha activation pathway that is independent of MAPKK.

1456
Ad-TAB1

Ready-to-use Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 / TAK1 binding protein Adenovirus. Ad-TAB1, Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 / TAK1 binding protein, TAB1,MGC57664,MAP3K7IP1 adenovirus 1456

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
3'-Tab1; MAP3K7IP1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAK1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Description (eCommerce)
TAB1 interacts with and regulates TAK1 (TGF-beta-activated kinase 1). TAK1 is a MAP kinase kinase kinase that regulates MAP kinase activity in TGF-beta-induced signaling pathways. TAB1 has also been shown to interact with and activate MAPK14/p38alpha.
Description (Vector)
TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
10454
Gene Name (eCommerce)
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Gene Name (Vector)
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Gene Symbol
TAB1
HGNC ID
HGNC:18157
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1515
ORF Size (bp)
1515 bp
Protein Name (eCommerce)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
RefSeq ID
NM_006116
RefSeq Synonyms
NM_153497, NM_006116, BC050554,
Research Areas
B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cytokine Signaling,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,NF-kB Signaling,Notch Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,developmental_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
TAB1 interacts with and regulates TAK1 (TGF-beta-activated kinase 1). TAK1 is a MAP kinase kinase kinase that regulates MAP kinase activity in TGF-beta-induced signaling pathways. TAB1 has also been shown to interact with and activate MAPK14/p38alpha.
UniGene ID
Hs.507681
UniProt ID (eCommerce)
Q15750

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.