Baculoviral IAP repeat-containing 3 Adenovirus

Name 
Ad-BIRC3
Cat No 
1446
Availability
Immediate
Categories
Adenovirus, Over-Expression

TRAF-interacting proteins include TANK (also designated I-TRAF), ILP, ML-IAP, XAF1, c-IAP and survivin. TANK binds to the conserved TRAF-C domain common to TRAF1, TRAF2 and TRAF3. ML-IAP, c-IAP1 and c-IAP2 are related to the inhibitor of apoptosis protein (IAP) family of Baculovirus proteins. The c-IAPs associate with TRAF1 and TRAF2 through their N-terminal BIR motif-containing domain. IAP-like protein (ILP) also contains an N-terminal BIR motif-containing domain. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. An additional IAP family member, survivin (also designated TIAP), is expressed in the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindles. Caspase-3 activity increases when a disruption of survivin-microtubule interactions occurs.

1446
Ad-BIRC3

Ready-to-use Baculoviral IAP repeat-containing 3 Adenovirus. Ad-BIRC3, Baculoviral IAP repeat-containing 3, AIP1,API2,MIHC,BIRC3,CIAP2,HAIP1,HIAP1,MALT2,RNF49 adenovirus 1446

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49
Description (Vector)
BIRC3 encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
Gene ID
330
Gene Name (Vector)
baculoviral IAP repeat containing 3
Gene Symbol
BIRC3
HGNC ID
HGNC:591
ORF Size (aa)
1815
ORF Size (bp)
1815 bp
RefSeq ID
NM_001165
RefSeq Synonyms
NM_182962, NM_001165, BC037420,
Species
human
UniGene ID
Hs.127799

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.