Baculoviral IAP repeat-containing 4 Adenovirus
The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.
1429
Ad-BIRC4/XIAP
Ready-to-use Baculoviral IAP repeat-containing 4 Adenovirus. Ad-BIRC4/XIAP, Baculoviral IAP repeat-containing 4, API3,ILP1,MIHA,XIAP,BIRC4 adenovirus 1429
Gene Reference Data
Alternate Names
API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2
Description (Vector)
XIAP encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Gene ID
331
Gene Name (Vector)
X-linked inhibitor of apoptosis
Gene Symbol
XIAP
HGNC ID
HGNC:592
ORF Size (aa)
1494
ORF Size (bp)
1494 bp
RefSeq ID
NM_001167
RefSeq Synonyms
NM_001204401, NM_001167, BC032729,
Species
human
UniGene ID
Hs.356076
Related Citations
- The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of Apoptosis Inducing Factor and X-linked Inhibitor of Apoptosis. Farrand L. etc, (2013), The Journal of Biological Chemistry
- 17AAG and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and ROS. Teneille Walker, ETC, (2010), Mol Cancer Ther
- 17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species. Teneille Walker, (2010), Mol Cancer Ther
- Inhibition of Multiple Protective Signaling Pathways and Ad. 5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma. Hossein A Hamed, (2010), Molecular Therapy
- XIAP Gene Expression Protects -cells and Human Islets from Apoptotic Cell Death. Hao Wu, etc, (2010), Mol. Pharmaceutics
- Mek1/2 Inhibitors And 17AAG Synergize To Kill Human Gi Tumor Cells In Vitro Via Suppression Of C-Flip-S Levels And Activation Of Cd95. Park MA, etc, (2009), Mol Cancer Ther
- Sorafenib And Vorinostat Kill Colon Cancer Cells By Cd95-Dependent And -Independent Mechanisms. Walker T, etc, (2009), Mol Pharmacol
- Bcl-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor And Sorafenib Lethality Via Autophagy And Overcome Blockade Of The Extrinsic Pathway To Facilitate Killing. Martin, AP. etc, (2009), Mol Pharmacol
- Vorinostat And Sorafenib Synergistically Kill Tumor Cells Via Flip Suppression And Cd95 Activation. Zhang, G., etc., (2008), Clinical Cancer Research
- Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Yacoub, A. etc, (2008), Molecular Cancer Therapeutics
- Regulation Of Gst-Mda-7 Toxicity In Human Glioblastoma Cells By Erbb1, Erk1/2, Pi3k, And Jnk1-3 Pathway Signaling. Yacoub, A., etc., (2008), Molecular Cancer Therapeutics
- Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors And 17-Allylamino-17-Demethoxygeldanamycin Synergize To Kill Human Gastrointestinal Tumor Cells In Vitro Via Suppression Of C-Flip-S Levels And Activation Of Cd95. Park, M., etc., (2008), Molecular Cancer Therapeutics
- Vorinostat And Sorafenib Increase Er Stress, Autophagy And Apoptosis Via Ceramide-Dependent Cd95 And Perk Activation. Park MA, etc, (2008), Cancer Biol Ther
- Low-Dose Bbr3610 Toxicity In Colon Cancer Cells Is P53-Independent And Enhanced By Inhibition Of Epidermal Growth Factor Receptor (Erbb1)-Phosphatidyl Inositol 3 Kinase Signaling. Mitchell, C., etc., (2007), Mol Pharmacol
- Extrinsic Pathway- And Cathepsin-Dependent Induction Of Mitochondrial Dysfunction Are Essential For Synergistic Flavopiridol And Vorinostat Lethality In Breast Cancer Cells. Mitchell, C. etc, (2007), Molecular Cancer Therapeutics
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.