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human DCLK1 Adenovirus

Name 
Ad-h-DCLK1
Cat No 
ADV-206654
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human DCLK1.

ADV-206654
Ad-h-DCLK1

Ready-to-use Adenovirus expressing Human DCLK1 (doublecortin like kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; doublecortin domain-containing protein 3A; doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; serine/threonine-protein kinase DCLK1
Description (eCommerce)
Doublecortin-like and CAM kinase-like 1 (DCAMKL1) is a probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. DCAMKL1 may also participate in functions of the mature nervous system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O15075].
Description (Vector)
DCLK1 encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. DCLK1 is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
Gene ID
9201
Gene Name (eCommerce)
doublecortin like kinase 1
Gene Name (Vector)
doublecortin like kinase 1
Gene Symbol
DCLK1
HGNC ID
HGNC:2700
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2190
ORF Size (bp)
2190 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase DCLK1
RefSeq ID
NM_004734
RefSeq Synonyms
NM_004734, NM_001330072, NM_001330071, NM_001195430, NM_001195416, NM_001195415, BC160043, BC152456,
Research Areas
Brain Development,Host-Virus Interactions,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Neurogenesis,Response to Virus,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Doublecortin-like and CAM kinase-like 1 (DCAMKL1) is a probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. DCAMKL1 may also participate in functions of the mature nervous system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O15075].
UniGene ID
Hs.717124
UniProt ID (eCommerce)
O15075

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.