Estrogen receptor 2 (ER beta) Adenovirus

Name 
Ad-ER-beta
Cat No 
1394
Availability
Immediate
Categories
Adenovirus, Over-Expression

Estrogen and progesterone receptors are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The C-terminal region of the estrogen receptor contains a ligand binding domain, the N-terminus serves as a transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER(alpha) and ER(beta), which are differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B), which arise from alternative splicing. In most cells, PR-B functions as a transcriptional activator of progesterone-responsive genes, whereas PR-A functions as a transcriptional inhibitor of all steroid hormone receptors. mPR is a membrane progestin receptor.

1394
Ad-ER-beta

Ready-to-use Estrogen receptor 2 (ER beta) Adenovirus. Ad-ERB, Estrogen receptor 2 (ER beta), ERB,ESR2,ESRB,5P152,NR3A2,ER-BETA,ESR-BETA adenovirus 1394

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2
Description (Vector)
ESR2 encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Gene ID
2100
Gene Name (Vector)
estrogen receptor 2
Gene Symbol
ESR2
HGNC ID
HGNC:3468
ORF Size (aa)
972
ORF Size (bp)
972 bp
RefSeq ID
NM_001437
RefSeq Synonyms
NM_001437, NM_001291723, NM_001291712, NM_001271877, NM_001271876, NM_001214903, NM_001214902, NM_001040276, NM_001040275, BC024181,
Species
human
UniGene ID
Hs.660607

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.