human CLN8 Adenovirus

Name 
Ad-h-CLN8
Cat No 
ADV-205487
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CLN8.

ADV-205487
Ad-h-CLN8

Ready-to-use Adenovirus expressing Human CLN8 (ceroid-lipofuscinosis, neuronal 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C8orf61; EPMR
Description (Vector)
CLN8 encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.
Gene ID
2055
Gene Name (Vector)
ceroid-lipofuscinosis, neuronal 8
Gene Symbol
CLN8
HGNC ID
HGNC:2079
ORF Size (aa)
933
ORF Size (bp)
933 bp
RefSeq ID
NM_018941
RefSeq Synonyms
NM_018941, BC136825, BC007725,
Species
human
UniGene ID
Hs.127675

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.