TCF-4/TCF7L2 Adenovirus
T cell factor-4 (Tcf-4, also known as TCF7L2) plays an important role in development and carcinogenesis. It directly binds to cytosolic β-catenin and facilitate its translocation to the nucleus. In the nucleus, these complexes induce expression various target genes.
This adenovirus contain full length human TCF4.
Reference: Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma. Science (275):1784-1787. 1997
1280
Ad-TCF4
Ready-to-use TCF-4/TCF7L2 Adenovirus. BV T cell factor-4 (Tcf-4) 1280 TCF7L2 TCF4
Related Citations
- Opposing roles of TCF7/LEF1 and TCF7L2 in cyclin D2 and Bmp4 expression and cardiomyocyte cell cycle control during late heart development. B Ye, etc, (2019), Laboratory Investigation
- The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. L Norton, etc, (2014), Nucleic Acids Research
- Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand. Sylvia F. Boj, etc, (2012), Cell
- The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/ß-Catenin Signaling Pathways. Guo W, etc, (2008), J Biol Chem
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.