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human CEP290 Adenovirus

Name 
Ad-h-CEP290
Cat No 
ADV-204992
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CEP290.

ADV-204992
Ad-h-CEP290

Ready-to-use Adenovirus expressing Human CEP290 (centrosomal protein 290). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
3H11Ag; Bardet-Biedl syndrome 14 protein; BBS14; cancer/testis antigen 87; centrosomal protein 290kDa; centrosomal protein of 290 kDa; Cep290; CT87; CTCL tumor antigen se2-2; JBTS5; LCA10; Meckel syndrome, type 4; MKS4; monoclonal antibody 3H11 antigen; Nephrocystin-6; nephrocytsin-6; NPHP6; POC3; POC3 centriolar protein homolog; prostate cancer antigen T21; rd16; SLSN6; tumor antigen se2-2
Description (eCommerce)
Centrosomal protein 290 (CEP290) is a member of the nephrocystins, a family of proteins involved in renal cystic diseases. CEP290 and the nephrocystins appear to play a role in cilia and basal body function. Loss-of-function mutations in CEP290 result in Joubert syndrome and related disorders characterized by brain malformations, developmental delay, ataxia, irregular breathing, renal disease, and hepatic fibrosis.
Description (Vector)
CEP290 encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.
Gene ID
80184
Gene Name (eCommerce)
centrosomal protein 290
Gene Name (Vector)
centrosomal protein 290
Gene Symbol
CEP290
HGNC ID
HGNC:29021
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7440
ORF Size (bp)
7440 bp
Protein Name (eCommerce)
Centrosomal protein of 290 kDa
RefSeq ID
NM_025114
RefSeq Synonyms
NM_025114, BC172566, BC156462,
Research Areas
Apoptosis,Brain Development,Cell Cycle,Cytoskeleton,DNA Damage/Repair,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,developmental_biology,cell_cycle,genetics,transcription_translation,neurobiology
Species
human
Target Sentence
Centrosomal protein 290 (CEP290) is a member of the nephrocystins, a family of proteins involved in renal cystic diseases. CEP290 and the nephrocystins appear to play a role in cilia and basal body function. Loss-of-function mutations in CEP290 result in Joubert syndrome and related disorders characterized by brain malformations, developmental delay, ataxia, irregular breathing, renal disease, and hepatic fibrosis.
UniGene ID
Hs.150444
UniProt ID (eCommerce)
O15078

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.