human CDK8 Adenovirus

Name 
Ad-h-CDK8
Cat No 
ADV-204862
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CDK8.

ADV-204862
Ad-h-CDK8

Ready-to-use Adenovirus expressing Human CDK8 (cyclin dependent kinase 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CDK8 protein kinase; cell division protein kinase 8; cyclin-dependent kinase 8; K35; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8; protein kinase K35
Description (eCommerce)
Cyclin-dependent kinase 8 (CDK8) associates with cyclin C and is a component of the RNA polymerase II holoenzyme complex which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. CDK8 has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery [taken from NCBI Entrez Gene (GeneID: 1024)].
Description (Vector)
CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Gene ID
1024
Gene Name (eCommerce)
cyclin dependent kinase 8
Gene Name (Vector)
cyclin dependent kinase 8
Gene Symbol
CDK8
HGNC ID
HGNC:1779
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1395
ORF Size (bp)
1395 bp
Protein Name (eCommerce)
Cyclin-dependent kinase 8
RefSeq ID
NM_001260
RefSeq Synonyms
NM_001346501, NM_001318368, NM_001260, BC107601, BC105950, BC104492, BC069634,
Research Areas
Breast Cancer,Cancer,Cell Cycle,EPO Signaling,Gene Expression,Hedgehog Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Metabolism/Metabolic Process,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,metabolism,signal_transduction
Species
human
Target Sentence
Cyclin-dependent kinase 8 (CDK8) associates with cyclin C and is a component of the RNA polymerase II holoenzyme complex which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. CDK8 has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery [taken from NCBI Entrez Gene (GeneID: 1024)].
UniGene ID
Hs.382306
UniProt ID (eCommerce)
P49336

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.