human CDC73 Adenovirus

Name 
Ad-h-CDC73
Cat No 
ADV-204783
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CDC73.

ADV-204783
Ad-h-CDC73

Ready-to-use Adenovirus expressing Human CDC73 (cell division cycle 73). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C1orf28; cell division cycle 73 Paf1/RNA polymerase II complex component-like protein; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; FIHP; HPTJT; HRPT1; HRPT2; hyperparathyroidism 2 protein; HYX; Paf1/RNA polymerase II complex component; parafibromin
Description (eCommerce)
Parafibromin, also known as HRPT2 (hyperparathyroidism 2 protein), has been identified as a tumor suppressor that is associated with hyperparathyroidism-jaw tumor syndrome, an autosomal dominant disease characterized by hyperparathyroidism due to parathyroid tumors and ossifying fibromas of the mandible and maxilla. Parafibromin is a component of the PAF1 complex that associates with RNA polymerase II and plays a role in mRNA 3’-end processing and transcription elongation. Parafibromin has been demonstrated to function as an inhibitor of the cell cycle.
Description (Vector)
CDC73 encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
Gene ID
79577
Gene Name (eCommerce)
cell division cycle 73
Gene Name (Vector)
cell division cycle 73
Gene Symbol
CDC73
HGNC ID
HGNC:16783
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1596
ORF Size (bp)
1596 bp
Protein Name (eCommerce)
Parafibromin
RefSeq ID
NM_024529
RefSeq Synonyms
NM_024529, BC065037, BC014351,
Research Areas
Cancer,Cell Cycle,Histone Modification,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Parafibromin, also known as HRPT2 (hyperparathyroidism 2 protein), has been identified as a tumor suppressor that is associated with hyperparathyroidism-jaw tumor syndrome, an autosomal dominant disease characterized by hyperparathyroidism due to parathyroid tumors and ossifying fibromas of the mandible and maxilla. Parafibromin is a component of the PAF1 complex that associates with RNA polymerase II and plays a role in mRNA 3’-end processing and transcription elongation. Parafibromin has been demonstrated to function as an inhibitor of the cell cycle.
UniGene ID
Hs.576497
UniProt ID (eCommerce)
Q6P1J9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.