human CD2AP Adenovirus

Name 
Ad-h-CD2AP
Cat No 
ADV-204625
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PLEKHS1.

ADV-204625
Ad-h-CD2AP

Ready-to-use Adenovirus expressing Human CD2AP (CD2 associated protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
adapter protein CMS; cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; CMS
Description (eCommerce)
CD2-associated protein (CD2AP) seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, it modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. It also controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. CD2AP may play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell and may anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. CD2AP is also required for cytokinesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5K6].
Description (Vector)
CD2AP encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
Gene ID
23607
Gene Name (eCommerce)
CD2 associated protein
Gene Name (Vector)
CD2 associated protein
Gene Symbol
CD2AP
HGNC ID
HGNC:14258
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1920
ORF Size (bp)
1920 bp
Protein Name (eCommerce)
CD2-associated protein
RefSeq ID
NM_012120
RefSeq Synonyms
NM_012120, BC069444,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Immunology,Signal Transduction,T-cell Receptor Signaling,VEGF Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
CD2-associated protein (CD2AP) seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, it modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. It also controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. CD2AP may play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell and may anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. CD2AP is also required for cytokinesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5K6].
UniGene ID
Hs.485518
UniProt ID (eCommerce)
Q9Y5K6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.