human CARS Adenovirus

Name 
Ad-h-CARS
Cat No 
ADV-204095
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human BLOC1S1.

ADV-204095
Ad-h-CARS

Ready-to-use Adenovirus expressing Human CARS (cysteinyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CARS1; CYSRS; cysteine translase; cysteine tRNA ligase 1, cytoplasmic; cysteine--tRNA ligase, cytoplasmic; Cysteinyl-tRNA synthetase; MGC:11246
Description (eCommerce)
Cysteinyl-tRNA synthetase (CARS) catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. The CARS gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [taken from NCBI Entrez Gene (GeneID:833)].
Description (Vector)
CARS encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. CARS is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.
Gene ID
833
Gene Name (eCommerce)
cysteinyl-tRNA synthetase
Gene Name (Vector)
cysteinyl-tRNA synthetase
Gene Symbol
CARS
HGNC ID
HGNC:1493
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2247
ORF Size (bp)
2247 bp
Protein Name (eCommerce)
Cysteine--tRNA ligase, cytoplasmic
RefSeq ID
NM_001751
RefSeq Synonyms
NM_139273, NM_001751, NM_001194997, NM_001014437, BC002880,
Research Areas
Cancer,Gene Expression,Translational Control,tRNA Binding
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Cysteinyl-tRNA synthetase (CARS) catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. The CARS gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [taken from NCBI Entrez Gene (GeneID:833)].
UniGene ID
Hs.274873
UniProt ID (eCommerce)
P49589

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.