human AVPR2 Adenovirus
This is an Adenovirus expressing Human AVPR2.
ADV-201849
Ad-h-AVPR2
Ready-to-use Adenovirus expressing Human AVPR2 (arginine vasopressin receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ADHR; DI1; DIR; DIR3; NDI; V2R
Description (Vector)
AVPR2 encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
Gene ID
554
Gene Name (Vector)
arginine vasopressin receptor 2
Gene Symbol
AVPR2
HGNC ID
HGNC:897
ORF Size (aa)
1116
ORF Size (bp)
1116 bp
RefSeq ID
NM_000054
RefSeq Synonyms
NM_001146151, NM_000054, BC112181, BC101484,
Species
human
UniGene ID
Hs.567240
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.