human AUH Adenovirus
This is an Adenovirus expressing Human ANKRD49.
ADV-201825
Ad-h-AUH
Ready-to-use Adenovirus expressing Human AUH (AU RNA binding methylglutaconyl-CoA hydratase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.
Gene ID
549
Gene Name (Vector)
AU RNA binding methylglutaconyl-CoA hydratase
Gene Symbol
AUH
HGNC ID
HGNC:890
ORF Size (aa)
933
RefSeq ID
NM_001698
RefSeq Synonyms
NM_001698, NM_001306190, BC020722,
Species
human
UniGene ID
Hs.175905
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.