human ATP6V1H Adenovirus

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; CGI-11; MSTP042; NBP1; nef-binding protein 1; protein VMA13 homolog; SFD; SFDalpha; SFDbeta; vacuolar ATP synthase subunit H; vacuolar ATPase subunit H; vacuolar proton pump subunit H; vacuolar proton pump subunit SFD; V-ATPase 50/57 kDa subunits; V-ATPase subunit H; VMA13; V-type proton ATPase subunit H

V-type proton ATPase subunit H (ATP6V1H) is a subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). ATP6V1H is involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UI12].

ATP6V1H encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

51606

ATPase H+ transporting V1 subunit H

ATPase H+ transporting V1 subunit H

ATP6V1H

HGNC:18303

9606.0

1452

1452 bp

V-type proton ATPase subunit H

NM_015941

NM_213620, NM_213619, NM_015941, BC025275,

Host-Virus Interactions,Immunology,Insulin Signaling,Lysosome,Metabolism/Metabolic Process,Neurobiology,Response to Virus,Signal Transduction

signal_transduction,infectious_disease,immunology,signal_transduction,metabolism,cell_biology,neurobiology,infectious_disease

human

V-type proton ATPase subunit H (ATP6V1H) is a subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). ATP6V1H is involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UI12].

Hs.491737

Q9UI12