human ATF2 Adenovirus

Name
Ad-h-ATF2

Cat No
ADV-201614

Availability
4-5 weeks

This is an Adenovirus expressing Human AMTN.

ADV-201614

Ad-h-ATF2

Ready-to-use Adenovirus expressing Human ATF2 (activating transcription factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Activating transcription factor 2; activating transcription factor 2 splice variant ATF2-var2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CREB2; CREB-2; CRE-BP1; cyclic AMP-dependent transcription factor ATF-2; cyclic AMP-responsive element-binding protein 2; HB16; histone acetyltransferase ATF2; TREB7

Description (eCommerce)

Activating transcription factor 2 (ATF2) is a leucine-zipper transcription factor that binds to the cAMP-responsive element (CRE). ATF2 is involved in regulating the expression of a variety of proteins that are important to oncogenesis. It is a substrate of the JNK/p38 and ATM/ATR protein kinases which regulate its transactivating activity in response to environmental signals.

Description (Vector)

ATF2 encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.

Gene ID

1386

Gene Name (eCommerce)

activating transcription factor 2

Gene Name (Vector)

activating transcription factor 2

Gene Symbol

ATF2

HGNC ID

HGNC:784

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1344

ORF Size (bp)

1344 bp

Protein Name (eCommerce)

Cyclic AMP-dependent transcription factor ATF-2

RefSeq ID

NM_001880

RefSeq Synonyms

NM_001880, NM_001256094, NM_001256093, NM_001256092, NM_001256091, NM_001256090, BC130337, BC130335, BC107698, BC026175,

Research Areas

Angiogenesis,B-cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,DNA Damage/Repair,Estrogen Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,PI3K/Akt Signaling,RAC1 Signaling,Rho Signaling,RNA Binding,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Viral Carcinogenesis,Zinc-finger

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology

Species

human

Target Sentence

UniGene ID

Hs.592510

UniProt ID (eCommerce)

P15336

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.