human APOBEC3A Adenovirus

Name
Ad-h-APOBEC3A

Cat No
ADV-201181

Availability
4-5 weeks

This is an Adenovirus expressing Human AIF1L.

ADV-201181

Ad-h-APOBEC3A

Ready-to-use Adenovirus expressing Human APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

A3A; ARP3; bK150C2.1; PHRBN

Description (Vector)

APOBEC3A is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

200315

Gene Name (Vector)

apolipoprotein B mRNA editing enzyme catalytic subunit 3A

Gene Symbol

APOBEC3A

HGNC ID

HGNC:17343

ORF Size (aa)

546

ORF Size (bp)

546 bp

RefSeq ID

NM_145699

RefSeq Synonyms

NM_145699, NM_001270406, BC144146, BC126416,

Species

human

UniGene ID

Hs.348983

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.