human ALS2 Adenovirus

Name 
Ad-h-ALS2
Cat No 
ADV-200818
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ADCK2.

ADV-200818
Ad-h-ALS2

Ready-to-use Adenovirus expressing Human ALS2 (ALS2, alsin Rho guanine nucleotide exchange factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ALS2CR6; alsin; ALSJ; amyotrophic lateral sclerosis 2 (juvenile); amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; amyotrophic lateral sclerosis 2 protein; IAHSP; PLSJ
Description (eCommerce)
Alsin contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. Alsin localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in the gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis [taken from NCBI Entrez Gene (Gene ID: 57679)].
Description (Vector)
ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
57679
Gene Name (eCommerce)
ALS2, alsin Rho guanine nucleotide exchange factor
Gene Name (Vector)
ALS2, alsin Rho guanine nucleotide exchange factor
Gene Symbol
ALS2
HGNC ID
HGNC:443
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3714
ORF Size (bp)
3714 bp
Protein Name (eCommerce)
Alsin
RefSeq ID
NM_020919
RefSeq Synonyms
NM_020919, NM_001135745, BC071576,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Axonogenesis,Neurobiology,Neurodegeneration,Neurodevelopment,Transport
Research Areas (Faceted)
neurobiology,cell_biology,neurobiology,developmental_biology,neurobiology,developmental_biology,cell_biology
Species
human
Target Sentence
Alsin contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. Alsin localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in the gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis [taken from NCBI Entrez Gene (Gene ID: 57679)].
UniGene ID
Hs.621812
UniProt ID (eCommerce)
Q96Q42

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.