human AKAP12 Adenovirus

Name 
Ad-h-AKAP12
Cat No 
ADV-200654
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AKAP12.

ADV-200654
Ad-h-AKAP12

Ready-to-use Adenovirus expressing Human AKAP12 (A-kinase anchoring protein 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
A kinase (PRKA) anchor protein 12; AKAP 250; AKAP-12; AKAP250; A-kinase anchor protein 12; A-kinase anchor protein 250 kDa; A-kinase anchor protein, 250kDa; Gravin; kinase scaffold protein gravin; Myasthenia gravis autoantigen; myasthenia gravis autoantigen gravin; Src-Suppressed C Kinase Substrate; SSeCKS
Description (eCommerce)
AKAP12/Gravin is a tumor suppressor protein belonging to the A-kinase anchoring protein family. A-kinase anchoring proteins function as molecular scaffolds for the subcellular compartmentalization of A- kinase signaling molecules. In addition to its role in cell signaling, AKAP12/Gravin has also been identified as an autoantigen in some cases of myasthenia gravis and has recently been shown to play a role in leukemogenesis.
Description (Vector)
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Gene ID
9590
Gene Name (eCommerce)
A-kinase anchoring protein 12
Gene Name (Vector)
A-kinase anchoring protein 12
Gene Symbol
AKAP12
HGNC ID
HGNC:370
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5055
ORF Size (bp)
5055 bp
Protein Name (eCommerce)
A-kinase anchor protein 12
RefSeq ID
NM_005100
RefSeq Synonyms
NM_144497, NM_005100, BC157067, BC156286,
Research Areas
Cytoskeleton,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
AKAP12/Gravin is a tumor suppressor protein belonging to the A-kinase anchoring protein family. A-kinase anchoring proteins function as molecular scaffolds for the subcellular compartmentalization of A- kinase signaling molecules. In addition to its role in cell signaling, AKAP12/Gravin has also been identified as an autoantigen in some cases of myasthenia gravis and has recently been shown to play a role in leukemogenesis.
UniGene ID
Hs.371240
UniProt ID (eCommerce)
Q02952

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.