human ABCC2 Adenovirus

Name 
Ad-h-ABCC2
Cat No 
ADV-200077
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ABCC2.

ADV-200077
Ad-h-ABCC2

Ready-to-use Adenovirus expressing Human ABCC2 (ATP binding cassette subfamily C member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ABC30; ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; CMOAT; cMRP; DJS; MRP2; multidrug resistance-associated protein 2
Description (eCommerce)
ATP-binding cassette sub-family C member (ABCC2) mediates hepatobiliary excretion of numerous organic anions. It may function as a cellular cisplatin transporter [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92887].
Description (Vector)
ABCC2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Gene ID
1244
Gene Name (eCommerce)
ATP binding cassette subfamily C member 2
Gene Name (Vector)
ATP binding cassette subfamily C member 2
Gene Symbol
ABCC2
HGNC ID
HGNC:53
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4638
ORF Size (bp)
4638 bp
Protein Name (eCommerce)
Canalicular multispecific organic anion transporter 1
RefSeq ID
NM_000392
RefSeq Synonyms
NM_000392, BC136419,
Research Areas
Cancer,Transport
Research Areas (Faceted)
cancer,cell_biology
Species
human
Target Sentence
ATP-binding cassette sub-family C member (ABCC2) mediates hepatobiliary excretion of numerous organic anions. It may function as a cellular cisplatin transporter [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92887].
UniGene ID
Hs.368243
UniProt ID (eCommerce)
Q92887

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.