human ABCA4 Adenovirus

Name
Ad-h-ABCA4

Cat No
ADV-200050

Availability
4-5 weeks

This is an Adenovirus expressing Human ABCA4.

ADV-200050

Ad-h-ABCA4

Ready-to-use Adenovirus expressing Human ABCA4 (ATP binding cassette subfamily A member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19; STGD; STGD1

Description (Vector)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Gene ID

Gene Name (Vector)

ATP binding cassette subfamily A member 4

Gene Symbol

ABCA4

HGNC ID

HGNC:34

ORF Size (aa)

6822

ORF Size (bp)

6822 bp

RefSeq ID

NM_000350

RefSeq Synonyms

NM_000350, BC172565, BC172262,

Species

human

UniGene ID

Hs.416707

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.