human AARS Adenovirus

Name 
Ad-h-AARS
Cat No 
ADV-200028
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AARS.

ADV-200028
Ad-h-AARS

Ready-to-use Adenovirus expressing Human AARS (alanyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
alanine tRNA ligase 1, cytoplasmic; alanine--tRNA ligase, cytoplasmic; Alanyl-tRNA synthetase; alanyl-tRNA synthetase, cytoplasmic; alaRS; CMT2N; EIEE29; renal carcinoma antigen NY-REN-42
Description (eCommerce)
Alanyl-tRNA synthetase, cytoplasmic (AARS) catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). AARS also edits incorrectly charged tRNA(Ala) via its editing domain [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49588].
Description (Vector)
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Gene ID
16
Gene Name (eCommerce)
alanyl-tRNA synthetase
Gene Name (Vector)
alanyl-tRNA synthetase
Gene Symbol
AARS
HGNC ID
HGNC:20
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2907
ORF Size (bp)
2907 bp
Protein Name (eCommerce)
Alanine--tRNA ligase, cytoplasmic
RefSeq ID
NM_001605
RefSeq Synonyms
NM_001605, BC011451,
Research Areas
Apoptosis,Gene Expression,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Neurodevelopment,Protein Folding,RNA Binding,RNA Processing,Translational Control,tRNA Binding
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,metabolism,neurobiology,developmental_biology
Species
human
Target Sentence
Alanyl-tRNA synthetase, cytoplasmic (AARS) catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). AARS also edits incorrectly charged tRNA(Ala) via its editing domain [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49588].
UniGene ID
Hs.315137
UniProt ID (eCommerce)
P49588

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.