mouse TFEB Over-expression AAV
This is an AAV expressing Mouse Tfeb.
AAV-281149
AAV-m-TFEB
Ready-to-use AAV expressing Mouse Tfeb (transcription factor EB). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bHLHe35; Tcfeb
Description (Vector)
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Gene ID
21425
Gene Name (Vector)
transcription factor EB
Gene Symbol
Tfeb
ORF Size (aa)
1605
ORF Size (bp)
1605 bp
RefSeq ID
NM_011549
RefSeq Synonyms
NM_011549, NM_001161723, NM_001161722, BC064789,
Species
mouse
UniGene ID
Mm.2305
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.