mouse TRIB3 Over-expression AAV

Name 
AAV-m-TRIB3
Cat No 
AAV-274961
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Trib3.

AAV-274961
AAV-m-TRIB3

Ready-to-use AAV expressing Mouse Trib3 (tribbles pseudokinase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3
Description (Vector)
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
Gene ID
228775
Gene Name (Vector)
tribbles pseudokinase 3
Gene Symbol
Trib3
ORF Size (aa)
987
ORF Size (bp)
987 bp
RefSeq ID
NM_175093
RefSeq Synonyms
NM_175093, BC012955,
Species
mouse
UniGene ID
Mm.276018

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.