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mouse TNPO2 Over-expression AAV

Name 
AAV-m-TNPO2
Cat No 
AAV-274776
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Tnpo2.

AAV-274776
AAV-m-TNPO2

Ready-to-use AAV expressing Mouse Tnpo2 (transportin 2 (importin 3, karyopherin beta 2b)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1110034O24Rik; AA414969; AI464345; AI852433; IPO3; Knpb2b; Kpnb2b; TRN2
Description (Vector)
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Gene ID
212999
Gene Name (Vector)
transportin 2 (importin 3, karyopherin beta 2b)
Gene Symbol
Tnpo2
ORF Size (aa)
2664
ORF Size (bp)
2664 bp
RefSeq ID
NM_145390
RefSeq Synonyms
NM_145390, NM_001122843, BC003275,
Species
mouse
UniGene ID
Mm.220357

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.