Disease Modeling
Advanced viral vector solutions for precise and reliable disease modeling and therapeutic research.
Benefits of Using AAV
for Disease Modeling
Targeted Delivery
AAV vectors can be engineered to target specific tissues or cells, making them ideal for disease modeling with tissue-specific conditions.
Stable Expression
AAV provides long-term gene expression, crucial for chronic diseases requiring extended observation.
Low Immunogenicity
AAV vectors have lower immune system activation, reducing interference with disease model results.
Non-pathogenic
AAV is non-pathogenic to humans, ensuring safe use in disease models without added risks.
How Vectors Work
for Disease Modeling
Vectors enable the delivery of specific genes to replicate or study disease conditions. By introducing disease-related genes or manipulating gene function (e.g., knock-in, knock-out, silencing), researchers can mimic genetic disorders and observe cellular effects. Vectors like AAV offer stable, long-term gene expression, ideal for chronic diseases. They also facilitate testing of potential therapies by introducing therapeutic genes or silencing disease-causing genes, helping develop targeted treatments. Overall, vectors provide valuable insights into disease mechanisms and therapeutic strategies.
AAV for Gene Therapy Disease modeling
Key Applications
of AAV in Disease Modeling
Genotyping
Simplifying genotyping with precise AAV-driven gene delivery.
Screening Validation and Toxicology
Enhancing screening and toxicology studies with reliable AAV tools.
Clinical Candidate Identification & Pre-IND Confirmation
Accelerating clinical readiness through AAV-powered candidate identification.
Induction of Disease State
Modeling disease states accurately with AAV for impactful research.
Why Use Vector Biolabs
Customizable Vectors
Customizable viral vectors, such as AAV, lentivirus, and adenovirus, to meet specific research needs, enabling tailored gene delivery for disease models.
High-Quality Vectors
Vectors undergo rigorous quality control, ensuring high purity, functionality, and consistent performance, which is crucial for reliable disease modeling.
Expertise and Support
Vector Biolabs offers expert support, helping researchers optimize their disease modeling experiments.
Rapid Turnaround
Offer fast production and delivery times, allowing you to accelerate their disease modeling projects and reduce overall timelines.
Scalable Solutions
Whether for small-scale experiments or large-scale applications, we provide scalable vector production to suit the needs of various research projects.
Use Case
A clinical-stage biotech company needed to develop a small molecule-based therapy to treat kidney disease. Traditionally, this would require creating transgenic mice expressing the human gene of their target, a process that takes 6 to 12 months. Instead, the company chose to use AAV to deliver the human gene into mice directly as the replacement for transgenic mouse model.
Vector Biolabs helped by constructing and producing AAV stocks, which were injected directly into the mice. This allowed the company to screen their small molecule library in vivo within weeks, saving 6 to 12 months of development time.
The best candidate from the screen is now in Phase 1 clinical trials.
Vector Biolabs helped by constructing and producing AAV stocks, which were injected directly into the mice. This allowed the company to screen their small molecule library in vivo within weeks, saving 6 to 12 months of development time.
The best candidate from the screen is now in Phase 1 clinical trials.
