mouse NIACR1 Over-expression AAV

Name 
AAV-m-NIACR1
Cat No 
AAV-265769
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Hcar2.

AAV-265769
AAV-m-NIACR1

Ready-to-use AAV expressing Mouse Hcar2 (hydroxycarboxylic acid receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Gpr109a; Gpr109b; HM74; mHM74b; Niacr1; PUMA-G; Pumag
Description (Vector)
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Gene ID
80885
Gene Name (Vector)
hydroxycarboxylic acid receptor 2
Gene Symbol
Hcar2
ORF Size (aa)
1083
ORF Size (bp)
1083 bp
RefSeq ID
NM_030701
RefSeq Synonyms
NM_030701, BC125296, BC120715,
Species
mouse
UniGene ID
Mm.440567

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.