mouse MAPK8IP1 Over-expression AAV
This is an AAV expressing Mouse Mapk8ip1.
AAV-264227
AAV-m-MAPK8IP1
Ready-to-use AAV expressing Mouse Mapk8ip1 (mitogen-activated protein kinase 8 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IB1; JIP-1; Jip1; mjip-2a; Prkm8ip; Skip
Description (Vector)
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
Gene ID
19099
Gene Name (Vector)
mitogen-activated protein kinase 8 interacting protein 1
Gene Symbol
Mapk8ip1
ORF Size (aa)
2097
ORF Size (bp)
2097 bp
RefSeq ID
NM_011162
RefSeq Synonyms
NM_011162, NM_001202446, NM_001202445, BC072578,
Species
mouse
UniGene ID
Mm.2720
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.