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mouse HOMER1 Over-expression AAV

Name 
AAV-m-HOMER1
Cat No 
AAV-261546
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Homer1.

AAV-261546
AAV-m-HOMER1

Ready-to-use AAV expressing Mouse Homer1 (homer scaffolding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1
Description (Vector)
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Gene ID
26556
Gene Name (Vector)
homer scaffolding protein 1
Gene Symbol
Homer1
ORF Size (aa)
561
RefSeq ID
NM_152134
RefSeq Synonyms
NM_152134, NM_147176, NM_011982, NM_001347598, NM_001284189, BC064041,
Species
mouse
UniGene ID
Mm.37533

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.