mouse FZD2 Over-expression AAV

Name 
AAV-m-FZD2
Cat No 
AAV-259746
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Fzd2.

AAV-259746
AAV-m-FZD2

Ready-to-use AAV expressing Mouse Fzd2 (frizzled class receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AL033370; AW456835; Fz10; Fzd10; Mfz10; Mfz10a
Description (Vector)
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Gene ID
57265
Gene Name (Vector)
frizzled class receptor 2
Gene Symbol
Fzd2
ORF Size (aa)
1713
ORF Size (bp)
1713 bp
RefSeq ID
NM_020510
RefSeq Synonyms
NM_020510, BC055727, BC049774,
Species
mouse
UniGene ID
Mm.36416

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.