mouse DNMT3A Over-expression AAV

Name 
AAV-m-DNMT3A
Cat No 
AAV-257356
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Dnmt3a.

AAV-257356
AAV-m-DNMT3A

Ready-to-use AAV expressing Mouse Dnmt3a (DNA methyltransferase 3A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MmuIIIA
Description (Vector)
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).
Gene ID
13435
Gene Name (Vector)
DNA methyltransferase 3A
Gene Symbol
Dnmt3a
ORF Size (aa)
2727
ORF Size (bp)
2727 bp
RefSeq ID
NM_007872
RefSeq Synonyms
NM_153743, NM_007872, NM_001271753, BC007466,
Species
mouse
UniGene ID
Mm.470389

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.