mouse CHTF8 Over-expression AAV

Name 
AAV-m-CHTF8
Cat No 
AAV-255489
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Chtf8.

AAV-255489
AAV-m-CHTF8

Ready-to-use AAV expressing Mouse Chtf8 (CTF8, chromosome transmission fidelity factor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
5830457O10Rik; Ctf8; Derpc
Description (Vector)
Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed|Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.
Gene ID
214987
Gene Name (Vector)
CTF8, chromosome transmission fidelity factor 8
Gene Symbol
Chtf8
ORF Size (aa)
1602
ORF Size (bp)
1602 bp
RefSeq ID
NM_145412
RefSeq Synonyms
NM_145412, BC023107,
Species
mouse
UniGene ID
Mm.476806

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.